Table 1.

Effects of postnatal MPTP (10, 20 and 30 mg/kg) on striatial DA, DOPAC, HVA and 3-MT in offspring exposed to prenatal MPTP or prenatal PBS. The percent changes based on the population (PBS mice) levels are enclosed by brackets below the respective concentrations. The results show that postnatal MPTP was more effective in reducing DA and its metabolites in the prenatal MPTP mice. However, for the 20 and 30 mg/kg doses of MPTP the significance was masked because those doses of MPTP also reduced DA and its metabolites in the prenatal PBS offspring.

DA and Metabolites (ng/mg protein)	Prenatal Exposure.	Postnatal MPTP Challenges (mg/kg)
		0	10	20	30 mg/kg
DA	PBS	157.3 ± 17.3 [0.0]	141.0 ± 5.50 [10.35]	34.5 ± 1.7 [78.06]	16.40 ± 2.0 [89.57]
	MPTP 10mg/kg	135.6 ± 4.80 [13.80]	48.0 ± 7.10 [69.96]	28.0 ± 2.0 [82.20]	3.95 ± 1.0 [97.49]
DOPAC	PBS	5.2 ± 0.76 [0.0]	6.00 ± 1.00 [15.38]	3.3 ± 0.4 [36.53]	1.95 ± 0.41 [62.5]
	MPTP 10mg/kg	5.9 ± 0.88 [+13.46]	1.04 ± 0.96 [80.0]	0.46 ± 0.58 [91.15]	0.41 ± 0.33 [92.11]
HVA	PBS	18.2 ± 0.80 [0.0]	17.5 ± 1.00 [3.85]	9.84 ± 0.6 [45.93]	6.0 ± 0.47 [67.03]
	MPTP 10mg/kg	15.2 ± 0.80 [16.48]	9.4 ± 0.66 [48.35]	8.3 ± 2.1 [54.39]	4.7 ± 0.70 [74.17]
3-MT	PBS	1.6 ± 0.20 [0.0]	1.2 ± 0.15 [25.0]	0.75 ± 12 [53.22]	0.54 ± 0.11 [66.25]
	MPTP 10mg/kg	0.54 ± 0.12 [66.25]	0.45 ± 0.11 [65.38)	0.32 ± 0.05 [80.0]	0.32 ± 0.06 [80.0]