Table 1. Individual p values comparing the seroresponse against listed individual HPV early proteins in the comparison of individuals with cancer, high- and low-grade lesions and asymptomatic smears.
Significantly differentially reactive E proteins (p <0.05) are highlighted with bold fonts. The antigens are ranked by p-value for discriminating individuals with cancer (column 2).
| Comparison (Number of Patients) |
No Lesions (280) vs. Cancer (93) |
Low Grade Lesions (LSIL)(123) vs. Cancer (93) |
High Grade Lesions (HSIL) (50) vs. Cancer (93) |
No Lesions (280) vs. Low Grade Lesions (LSIL) (123) |
No Lesions (280) vs. High Grade Lesions (HSIL)(50) |
Low Grade Lesions (LSIL) (123) VS High Grade Lesions (HSIL)(50) |
|---|---|---|---|---|---|---|
| HPV-31 E7 | 5.87E-09 | 3.87E-05 | 0.0500 | 0.3900 | 0.7441 | 0.9359 |
| HPV-18 E7 | 7.33E-08 | 0.0003 | 0.3283 | 0.5208 | 0.3101 | 0.9359 |
| HPV-33 E6 | 0.0037 | 0.0417 | 0.3045 | 0.4123 | 0.4606 | 0.9359 |
| HPV-35 E7 | 0.0040 | 0.0228 | 0.3796 | 0.9866 | 0.7929 | 0.9359 |
| HPV-16 E7 | 0.0052 | 0.0050 | 0.3045 | 0.3900 | 0.1890 | 0.9359 |
| HPV-16 E6 | 0.0055 | 0.2773 | 0.4246 | 0.3845 | 0.5425 | 0.9862 |
| HPV-16 E1 | 0.0077 | 0.1926 | 0.8683 | 0.3845 | 0.3101 | 0.9359 |
| HPV-11 E1 | 0.0139 | 0.4976 | 0.4427 | 0.1939 | 0.6589 | 0.9359 |
| HPV-33 E7 | 0.0171 | 0.0050 | 0.3045 | 0.7503 | 0.9685 | 0.9359 |
| HPV-33 E5 | 0.0174 | 0.0417 | 0.1198 | 0.8140 | 0.9646 | 0.9862 |
| HPV-53 E1 | 0.0176 | 0.0968 | 0.6998 | 0.8140 | 0.5425 | 0.9359 |
| HPV-31 E1 | 0.0212 | 0.3483 | 0.8561 | 0.4123 | 0.4456 | 0.9970 |
| HPV-33 E1 | 0.0275 | 0.5247 | 0.8529 | 0.5208 | 0.4817 | 0.9862 |
| HPV-16 E4 | 0.0280 | 0.2272 | 0.5426 | 0.8140 | 0.8443 | 0.9640 |
| Number of Differentially Reactive E Proteins |
14 | 7 | 1 | 0 | 0 | 0 |