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. 2010 Jul 3;236(1):167–179. doi: 10.1007/s00232-010-9271-4

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© The Author(s) 2010

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Fig. 6 — a Cytotoxicity to MeT-5A, L929 and SK-MEL-28 cells exposed to Nd–Fe–B magnets at different time intervals. Cytotoxicity of SPIONs to MeT-5A (b), L929 (c) and SK-MEL-28 (d) cells with additional exposure to Nd–Fe–B magnets for different time intervals. a When exposed to Nd–Fe–B magnets only, no statistically significant decrease in cell survival for all three cell lines was observed. b At longer exposures to Nd–Fe–B magnets (60 and 90 min), concentrations of SPIONs >25 μg/ml statistically significantly decreased survival of MeT-5A cells. c, d The highest concentrations of SPIONs (50 and 100 μg/ml) significantly decreased survival of L929 and SK-MEL-28 cells independently of the duration of exposure to an external magnetic field (P ≤ 0.05 vs. untreated control cells; for the purpose of clarity, we omitted asterisks representing statistically significant differences)