Table 7.

Summary of toothpaste studies (3)

Author	Cancer Dx	Cancer Tx	Study type	Time of assessment	Final N/intervention 1	Final N/intervention 2
Papas et al. 2008 [50]	Not specified (assumed H&Na)	H&Na RTb	RCTc	Some post-RTb (0–15 years), some still actively treated with RTb	N = 23	N = 19
			Double blind	Assessed at baseline, then 1,2, 4, 6, 8, 10, and 12 months	Enamelon (dual phase remineralizing toothpaste)	Conventional toothpaste
Toljanic et al. 1996 [49]	H&Na	RTb	RCTc	Post-RTb	All were given a toothbrush and 1.1% neutral sodium fluoride gel every night for 5 min, cross-over at 3 months
			Double blind	Assessments done at start of study, 1, 2, 3, 4, 5, and 6 months	N = 19 (self control)	N = 19 (self control)
					Group 1 (10), group 2 (9)	Group 1 (10), group 2 (9)
					Group 1: toothpaste with lactoperoxidase and glucose oxidase then placebo toothpaste	Group 2: placebo toothpaste then toothpaste with lactoperoxidase and glucose oxidase
van Steenberghe et al. 1994 [48]	Tumors in the major salivary gland area	RTb	RCTc	Minimum 3 months post-RTb	Prior to study, all patients received 2 sessions of oral hygiene instructions (OHI) which included supervised toothbrushing and interproximal plaque control. At baseline, all patients received a professional cleaning. Cross-over on day 42
			Single blind (patient)	Assessments done at days 0, 10, 42, and 52	N = 12 (self control)	N = 12 (self control)
					6 On each group	6 On each group
					Biotene toothpaste then Sensodyne toothpaste on day 42	Sensodyne toothpaste then Biotene toothpaste on day 42

^aHead and neck

^bRadiation

^cRandomized control trial

^dChemotherapy