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. 2010 May 7;18(8):1007–1021. doi: 10.1007/s00520-010-0873-2

Table 8.

Summary of chlorhexidine studies (3)

Author	Cancer Dx	Cancer Tx	Study type	Time of assessment	Final N/intervention 1	Final N/intervention 2
Bergmann et al. 1992 [39]	Acute myelogenous leukemia	CT^d	RCT^c	During antineoplastic treatment	N = 10	N = 10
Bergmann et al. 1992 [39]	Acute myelogenous leukemia	CT^d	Blinding unknown	Assessed on days 1, 14, and 28 of CT^d	0.1% Chlorhexidine rinse with mechanical removal of plaque and calculus on day 1	0.1% Chlorhexidine rinse

Joyston-Bechal et al. 1992 [51]	H&N^a	RT^b	Before and after	Assessed 1 week before RT^b, once weekly during 4 weeks of treatment, and at approximately 6, 8, 10, 12, 26, 40, and 52 weeks after start of RT^b	N = 25	NA
Joyston-Bechal et al. 1992 [51]	H&N^a	RT^b	Before and after		0.2% Chlorhexidine, diluted 1:1 with water twice a day for 1 week before RT, during RT, and 4 weeks after radiation	NA

Meurman et al. 1991 [47]	Hodgkin's and non-Hodgkin's disease	CT^d	RCT^c	During combination CT^d	All patients went through a rinse period with 0.05% sodium fluoride solution from weeks 2 to 4
			Double-blind cross-over study	Assessed before anticancer treatment began and before and after each period of rinsing with different type of mouthwash	In addition, patients in the amine-stannous fluoride group also had 0.05% sodium fluoride solution from weeks 6 to 8
					N = 51 (self control)	N = 51 (self control)
					0.12% Chlorhexidine rinse	0.025% Amine-stannous fluoride mouth rinse

^aHead and neck

^bRadiation

^cRandomized control trial

^dChemotherapy