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Normalized fluorescence of ex vivo tumor and muscle tissues 24 hours after injection of NIR fluorescent imaging agents. ανβ3–integrin -targeted imaging agents showed significantly higher tumor specificity relative to non-targeted NIR fluorescent nanoparticles (p<0.01). Data for cypate-PFC-tNPs (2×1013 particles/ml, n=3 tumors) and cypate-cRGDfK (n=3) and for cypate-PFC-NPs (2×1013 particles/ml, n=2 tumors). Error bars indicate standard deviation.
