Table 1.

Histological observations in preterm newborn rabbits treated with 2% Mini-B, 2% SP-C33, 2% Mini-B + 2% SP-C33, all in DPPC/POPG (68:31, w/w), Curosurf, or non-treated controls^a

Treatment	n	Grade of expansion (0–4)	Epithelial necrosis (0–3)	Alveolar volume density (%)
Curosurf	12	3 (1–3)*	1 (0–1)#	64 (52–71)**, ***
2% SP-C33	11	1 (0–2)#	1 (0–2)	53 (49–57)
2% Mini-B	12	1 (0–2)#	1 (0–2)	52 (38–59)
2% SP-C33 + 2% Mini-B	10	2 (1–3)##,x, §	1 (0–2)	58 (50–65)x, §
Non-treated controls	11	0 (0–1)	1.5 (1–3)	57 (48–62)

Values are given as median (range). n = Number of animals.

^aAll surfactants were administered at a dose of 80 mg phospholipid/ml, 2.5 ml/kg.

^*p < 0.01 vs. all other groups

^**p < 0.02 vs. 2% SP-C33 + 2% Mini-B

^***p < 0.001 vs. 2% SP-C33, 2% Mini-B and non-treated controls, respectively.

^#p < 0.05 vs. non-treated controls

^##p < 0.01 vs. non-treated controls.

^xp < 0.01 vs. 2% Mini-B.

^§p < 0.05 vs. 2% SP-C33.