Table 1.
Antigen expression pattern and peak pattern of GeneScan analysis before and after Rx
| Case | Before Rx |
After Rx |
Peak pattern of GeneScan analysis before and after Rx | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| first biopsy |
second biopsy |
first biopsy |
second biopsy |
third biopsy |
||||||||
| IHC | FCM | IHC | FCM | IHC | FCM | IHC | FCM | IHC | FCM | |||
| Group A (4 cases) | ||||||||||||
| 1 | CD20+ | NA | nd | nd | CD20+ | NA | CD20– | NA | nd | nd | change | |
| CD79a+ | ||||||||||||
| 2 | CD20+ | NA | CD20+ | CD20+ | CD20− | NA | nd | nd | nd | nd | change | |
| CD79a+ | ||||||||||||
| 3 | CD20+ | CD20+ | nd | nd | CD20− | CD20− | nd | nd | nd | nd | NA | |
| CD79a+ | CD19+ | |||||||||||
| 4 | CD20+ | CD20+ | nd | nd | CD20+ | CD20− | nd | nd | nd | nd | NA | |
| CD19+ | ||||||||||||
| Group B (17 cases) | ||||||||||||
| 5–21 | CD20+ | CD20+* | CD20+ | CD20+* | CD20+ | CD20+* | CD20+ | NA | CD20+ | NA | change | 6 cases |
| identical | 1 case | |||||||||||
| Group C (2 cases) | ||||||||||||
| 22 | CD20+ | CD20− | nd | nd | CD20+ | CD20− | nd | nd | nd | nd | identical | |
| CD19+ | CD19+ | |||||||||||
| 23 | CD20+ | NA | CD20+ | CD20− | CD20+ | CD20+ | CD20+ | CD20+ | nd | nd | change | |
| CD19+ | ||||||||||||
Rx = Rituximab; IHC = immunohistochemistry; FCM = flow cytometry; NA = data not available; nd = not done.
*
Data were available in part of the cases.