Table 1.
| PBCS | SEARCH | Pooled Study | |||||||
|---|---|---|---|---|---|---|---|---|---|
| rs# (Location) |
No.3 (%) Controls |
No.3 (%) Cases |
OR3 (95% CI) | No.3 (%) Controls |
No.3 (%) Cases |
OR3 (95% CI) | No.3 (%) Controls |
No.3 (%) Cases |
OR3 (95% CI) |
| rs931127 (−3092 A>G) | |||||||||
| AA | 681 (30.6) | 814 (34.2) | 1.00 | 622 (31.0) | 623 (28.4) | 1.00 | 1306 (32.9) | 1437 (32.2) | 1.00 |
| AG | 947 (42.5) | 1107 (46.6) | 1.02 (0.90, 1.17) | 970 (48.4) | 1099 (50.1) | 0.88 (0.77, 1.02) | 1917 (48.3) | 2209 (49.6) | 0.95 (0.86, 1.05) |
| GG | 330 (14.8) | 342 (14.4) | 1.15 (0.96, 1.38) | 412 (20.6) | 470 (21.4) | 0.88 (0.74, 1.04) | 742 (18.7) | 812 (18.2) | 1.00 (0.88, 1.13) |
| per allele | 1.06 (0.97, 1.16) | 0.93 (0.86, 1.02) | 0.99 (0.93, 1.06) | ||||||
| rs3741378 (Ex3−135 C>T) | |||||||||
| CC | 1514 (68.0) | 1759 (74.0) | 1.00 | 1525 (74.9) | 1640 (74.7) | 1.00 | 3040 (75.7) | 3402 (76.1) | 1.00 |
| CT | 432 (19.4) | 476 (20.0) | 1.06 (0.92, 1.23) | 472 (23.2) | 524 (23.9) | 0.97 (0.84, 1.12) | 905 (22.5) | 1000 (22.4) | 1.01 (0.91, 1.12) |
| TT | 31 (1.4) | 37 (1.6) | 0.97 (0.60, 1.58) | 40 (2.0) | 30 (1.4) | 1.43 (0.89, 2.31) | 72 (1.8) | 67 (1.5) | 1.20 (0.86, 1.68) |
| per allele | 1.04 (0.92, 1.19) | 1.02 (0.90, 1.16) | 1.03 (0.94, 1.13) | ||||||
| rs746429 (Ex14+14 C>T) | |||||||||
| GG | 637 (28.6) | 697 (30.93) | 1.00 | 816 (40.9) | 917 (42.3) | 1.00 | 1454 (36.7) | 1616 (36.5) | 1.00 |
| GA | 969 (43.5) | 1113 (49.4) | 0.95 (0.83, 1.10) | 950 (47.6) | 992 (45.7) | 1.08 (0.95, 1.23) | 1920 (48.5) | 2106 (47.6) | 1.02 (0.93, 1.12) |
| AA | 356 (16.0) | 445 (19.7) | 0.87 (0.73, 1.04) | 231 (11.6) | 261 (12.0) | 0.99 (0.81, 1.22) | 588 (14.8) | 706 (15.9) | 0.93 (0.82, 1.07) |
| per allele | 0.94 (0.86, 1.02) | 1.02 (0.93, 1.12) | 0.98 (0.92, 1.04) | ||||||
1
Abbreviations: OR=odds ratio, CI=confidence intervals,
2
Cases and controls may not add up the totals because of missing values;
3
Adjusted for age and study site.