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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Immunol Rev. 2010 May;235(1):172–189. doi: 10.1111/j.0105-2896.2010.00903.x

Fig. 6. PtdSer and galectin-9 binding regions in the mTIM-3 IgV domain.

Fig. 6

Ribbon diagram of the mTIM-3 IgV domain, with β-strands of the GFC β-sheet labeled. The opposite sides of the IgV domain engaged in PtdSer or galectin-9 binding are indicated. The residues at the FG and CC’ loops interacting with PtdSer and coordinating the metal ion (green sphere) are shown with stick drawing and with the same color coding as in Fig. 4A. The side chains of two Asn residues which can be N-glycosylated are shown as spheres and with carbons in orange, nitrogen in blue, and oxygen in red. The complex carbohydrate modifications would extend outwards from these residues. Galectin-9 can bind to some specific motif of these N-linked carbohydrates. Residues polymorphic between BALB/c and HBA in the β-strand A and the BC loop have been colored pink.