Table 1.
Summary of Protein Biomarkers and QD–Antibody Conjugates for Detection and Differentiation of Malignant Hodgkins’ and Reed-Sternberg (HRS) Cells from Infiltrating T and B cellsa
| biomarkers/cell type | CD15 | CD30 | CD45 | Pax5 |
|---|---|---|---|---|
| H/RS cell | + | + | − | + |
| T cell | − | − | + | − |
| B cell | − | − | + | + |
| cellular location | membrane and golgi | membrane and golgi | membrane/cytoplasmic | nuclear |
| QD emission spectra (wavelength) | 705 nm | 605 nm | 565 nm | 655 nm |
| coding color | white | red | green | blue |
a
Notes: The symbols + and − denote positive and negative biomarker expression, respectively.