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. Author manuscript; available in PMC: 2010 Aug 3.
Published in final edited form as: Chemistry. 2009 Jul 13;15(28):6910–6919. doi: 10.1002/chem.200900794

Table 1.

Selected optimization studies.

Entry Pd source (mol %) Cs2CO3 (equiv) Substrate Conc. (M) Yield (%)[a] ee (%)[b]
1 Pd2(dba)3·CHCl3 (5) 1.0 0.02 90 84
2 Pd2(dba)3·CHCl3 (5) 0.7 0.02 75 92
3 Pd2(dba)3·CHCl3 (2.5) 1.0 0.02 89 66
4 Pd2(dba)3·CHCl3 (1.25) 1.0 0.08 75 85
5 [Pd(π-C3H5)Cl]2 (2) 1.0 0.17 88–93 87
6 [Pd(π-C3H5)Cl]2 (1.25) 1.0 0.08 83 92
[a]

Isolated yield

[b]

Enantioselectivities were determined by chiral HPLC.