Skip to main content
. Author manuscript; available in PMC: 2010 Aug 3.
Published in final edited form as: Chemistry. 2009 Jul 13;15(28):6910–6919. doi: 10.1002/chem.200900794

Table 2.

Selected optimization of aziridination reaction.

graphic file with name nihms222469u1.jpg
Entry Catalyst (mol %) PhI=NTs (equiv) Solvent Temp.(°C) Yield (%)[a]
1 Cu(acac)2 (10) 2 CH3CN 0 to rt 28
2 CuTc (20) 2 CH3CN 0 to rt 29–40
3 Cu(OTf)2 (20) 2 CH3CN rt trace
4 CuOTf (10) 2 DME rt 0
5 CuOTf (30) 3 CH3CN rt 16
6 CuOTf (10) 2 benzene 0 to rt 30
7 CuOTf (50) 2 benzene rt 41
8 CuOTf (100) 2 benzene rt 47
9 Cu(py)2Cl2 (100) 2 DCM rt <30
10 Catalyst 13 (50) 5 benzene[b] 0 to rt 52
11 Catalyst 14 (50) 5 benzene 0 to rt 51
[a]

Isolated yield.

[b]

Decomposition was observed when CH3CN was used as solvent.