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Oxidative ring-opening of aziridine 12.
| Entry | Conditions | Results |
|---|---|---|
| 1 | IBX, β-cyclodextrin, aqueous acetone, rt | recovered 12 only |
| 2 | IBX, β-cyclodextrin, aqueous dioxane, 50–60 °C | decomposition of 12 |
| 3 | DMSO, 80 °C | 5 (42% yield[a]) |
| 4 | DMSO, molecular sieves, 80 °C | decomposition of 12 |
| 5 | DMSO, microwave, 150 °C | decomposition of 12 |
| 6 | DMSO, In(OTf)3 (0.7 equiv), 80 °C | 5 (91% yield[a]) |
Isolated yield.
