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Combined experimental and bioinformatic approaches identify miRNA-guided mRNA cleavage sites in mouse embryonic stem cells. (A) Cumulative RACE tag abundances in WT (blue) and Ago2−/− (red) libraries as a function of overlap with predicted miRNA target sites with 2 or fewer non-GU mismatches. (B) Same as in (A), but for randomized miRNAs. See also Supplementary Table S3 and Figure S3.
