Table II.

Results of multivariate analysis of transplant outcome by donor and recipient IL-1 genotype

Outcome	N1/N2	Relative risk (95% confidence interval)	P-value
Grade 2–4 acute GVHD
T-allele absent in recipient and donor	56/94	1·00	0·682*
T-allele present in the recipient	50/79	1·19 (0·81–1·75)	0·369
T-allele present in the donor	50/83	1·01 (0·69–1·49)	0·947
T-allele present in recipient and donor	63/112	0·95 (0·66–1·36)	0·790
Grade 3–4 acute GVHD
T-allele absent in recipient and donor	28/94	1·00	0·095*
T-allele present in the recipient	33/79	1·52 (0·92–2·53)	0·104
T-allele present in the donor	20/83	0·78 (0·44–1·39)	0·397
T-allele present in recipient and donor	33/112	0·98 (0·59–1·61)	0·923
Chronic GVHD
T-allele absent in recipient and donor	53/101	1·00	0·739*
T-allele present in the recipient	43/85	1·01 (0·67–1·52)	0·958
T-allele present in the donor	53/94	1·22 (0·83–1·79)	0·313
T-allele present in recipient and donor	64/122	1·10 (0·76–1·59)	0·611
Transplant-related mortality
T-allele absent in recipient and donor	58/104	1·00	0·504*
T-allele present in the recipient	49/90	1·14 (0·78–1·67)	0·508
T-allele present in the donor	53/102	0·90 (0·62–1·31)	0·592
T-allele present in recipient and donor	75/130	1·16 (0·82–1·64)	0·397
Relapse
T-allele absent in recipient and donor	5/104	1·00	0·942*
T-allele present in the recipient	6/90	1·41 (0·43–4·64)	0·567
T-allele present in the donor	5/102	1·06 (0·31–3·68)	0·923
T-allele present in recipient and donor	7/130	1·21 (0·38–3·82)	0·742
Overall mortality
T-allele absent in recipient and donor	61/104	1·00	0·528*
T-allele present in the recipient	54/90	1·16 (0·80–1·68)	0·427
T-allele present in the donor	57/102	0·93 (0·65–1·33)	0·691
T-allele present in recipient and donor	81/130	1·16 (0·83–1·62)	0·385

N1, number of events; N2, number evaluable.

^*3-degree freedom test.