Table 1.
Experimental designs for the leg rotation and blood signal nulling protocols. R2* was measured under each experimental condition indicated; note that the difference in R2* between the free flow/straight leg conditions in the leg rotation and blood signal nulling protocols reflects the blood’s contribution to R2*. The diffusion tensor was measured only in the free flow conditions under the leg rotation protocol.
| Protocol | Leg Position | Occlusion |
|
|---|---|---|---|
| No | Yes | ||
| Leg Rotation | Extended | Free flow/Straight leg | Occluded flow/Straight leg |
| Rotated | Free flow/Rotated leg | Occluded flow/Rotated leg | |
| Blood Signal Nulling | Extended | Free flow/Straight leg (VASO) | Occluded flow/Straight leg (VASO) |