Table 2.
Risk of advanced and non-advanced colorectal adenomas according to location or strength and type of family history of colorectal cancer (CRC)*
| Category | Number of men† | Odds ratio (95% CI) | ||||
|---|---|---|---|---|---|---|
| Advanced adenomas |
Non-advanced adenomas |
No reported adenomas |
Advanced vs. non- advanced adenomas |
Advanced adenomas vs. no adenomas |
Non-advanced adenomas vs. no adenomas |
|
| n=1,496 | n=1,507 | n=24,959 | ||||
| Risk among all men | 312/1,184‡ | 313/1,194‡ | 3,457/21,502‡ | 0.98 (0.82–1.17) | 1.67 (1.47–1.91) | 1.70 (1.49–1.94) |
| Risk of having only adenoma in the distal colon§ | 121/497‡ | 121/419‡ | - | 0.82 (0.61–1.09) | 1.57 (1.28–1.93) | 1.92 (1.56–2.36) |
| Risk of having only adenomas in the rectum§ | 25/159‡ | 27/136‡ | - | 0.78 (0.43–1.41) | 1.02 (0.67–1.56) | 1.31 (0.86–1.99) |
| Risk of having only proximal adenomas§ | 87/242‡ | 121/479‡ | - | 1.37 (1.00–1.89) | 2.21 (1.72–2.83) | 1.61 (1.31–1.97) |
| Age at diagnosis of the youngest first-degree relative with CRC (in years) | ||||||
| No family history | 1,184 | 1,194 | 21,502 | 1 (ref) | 1 (ref) | 1 (ref) |
| Before age 50 | 24 | 25 | 290 | 0.95 (0.54–1.68) | 1.48 (0.97–2.26) | 1.56 (1.03–2.36) |
| Age 50–59 | 59 | 48 | 559 | 1.22 (0.83–1.81) | 1.93 (1.47–2.55) | 1.58 (1.17–2.14) |
| Age 60–69 | 92 | 92 | 982 | 1.00 (0.74–1.36) | 1.78 (1.42–2.23) | 1.78 (1.42–2.22) |
| ≥ age 70 | 110 | 120 | 1,222 | 0.90 (0.68–1.18) | 1.68 (1.37–2.06) | 1.87 (1.53–2.28) |
| P for linear trend ** | 0.35 | 0.94 | 0.19 | |||
| Affected family member†† | ||||||
| Parent | ||||||
| No | 1,233 | 1,250 | 22,036 | 1 (ref) | 1 (ref) | 1 (ref) |
| Yes | 263 | 257 | 2,923 | 1.03 (0.85–1.25) | 1.59 (1.38–1.83) | 1.54 (1.34–1.78) |
| Sibling | ||||||
| No | 1,422 | 1,436 | 24,277 | 1 (ref) | 1 (ref) | 1 (ref) |
| Yes | 74 | 71 | 682 | 0.95 (0.67–1.34) | 1.71 (1.33–2.21) | 1.80 (1.39–2.33) |
| Number of first-degree relatives with CRC | ||||||
| None | 1,184 | 1,194 | 21,502 | 1 (ref) | 1 (ref) | 1 (ref) |
| 1 | 264 | 268 | 2,913 | 0.97 (0.80–1.17) | 1.68 (1.46–1.94) | 1.74 (1.51–2.00) |
| ≥2 | 33 | 29 | 263 | 1.08 (0.65–1.79) | 2.31 (1.59–3.35) | 2.14 (1.45–3.17) |
| P for linear trend | 0.91 | <.0001 | <.0001 | |||
The multinomial logistic regression models were adjusted for age (in 5-yr age groups), history of endoscopy prior to study entry (yes/no), routine screening versus other indications for any endoscopy, aspirin use (>2 times/wk versus ≤ 2 times/wk), use of multivitamins (current, former, never), smoking (never, quit ≤10 yr ago, quit>10 yr ago, current, missing) consumption of red meat (quintiles), alcohol (0, 0-<10, 10-<20, 20-<30, ≥30 g/d); intake of folate (quintiles), calcium (quintiles), BMI (quintiles), physical activity (quintiles), total energy intake (quintiles).
Due to missing values, not all totals add up to 1,496, 1,507 or 24,959.
Men with a family history of CRC / without family history of CRC.
Restricted to men who had only adenomas at one location. Similar conclusions were obtained when we focused on men who had at least one adenoma at the studied location.
This test was based on evaluating an ordinal variable for the age of diagnosis among cases only (4=before age 50, 3=age 50–59, 2= age 60–69, 1=≥ age 70).
Categories are not mutually exclusive. Estimates are mutually adjusted.