Table II.
Formulations | 1 hour | 1 day | 1 week |
---|---|---|---|
Varying P85 | |||
0% P85 | 10.8 ± 1.7 | 38.2 ± 2.5 | 54.7 ± 3 |
1% P85 | 10.2 ± 0.6 | 33.6 ± 1.1 | 51.8 ± 1.1 |
2.5% P85 | 10.4 ± 0.5 | 28.2 ± 0.5† | 52.4 ± 0.4 |
5% P85 | 10.4 ± 0.4 | 38.4 ± 2.8 | 54.4 ± 1.9 |
Varying Mw | |||
PLGA 2A | 10.4 ± 0.5‡ | 28.2 ± 0.5‡ | 52.4 ± 0.4¥ |
PLGA 3A | 11.3 ± 1.0Ŧ | 30.0 ± 0.7‡ | 71.4 ± 3.8 |
PLGA 4A | 15.2 ± 0.7* | 47.0 ± 2.3 | 74.9 ± 3.8 |
PLGA 4.5A | 21.0 ± 1.4 | 55.1 ± 3.1 | 75.6 ± 4.3 |
PLGA 7E | 18.0 ± 0.6 | 51.2 ± 1.5 | 69.9 ± 1.3 |
Varying Loading | |||
0.5% loading dose | 10.6 ± 0.2 | 25.3 ± 2.8§ | 57.4 ± 2.9§ |
1% loading dose | 10.4 ± 0.5 | 28.2 ± 0.5§ | 52.4 ± 0.4§ |
2% loading dose | 14.2 ± 0.6 | 49.0 ± 2.1 | 76.7 ± 4.3 |
5% loading dose | 29.9 ± 2.7** | 66.3 ± 1.3 | 82.5 ± 1.4 |
All values shown as ± Standard Error.
Indicates significant difference (p<0.05) from all other varying P85 formulations
Indicates significant difference (p<0.05) from PLGA 4A, 4.5A, and 7E
Indicates significant difference (p<0.05) from PLGA 4.5A, and 7E
Indicates significant difference (p<0.05) from PLGA 2A and 4.5A
Indicates significant difference (p<0.05) from all other Mw formulations
Indicates significant difference (p<0.05) form all other drug loading formulations
Indicates significant difference (p<0.05) from 2% and 5% drug loading