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. 2010 Jul 14;4:17. doi: 10.3389/fncel.2010.00017

Figure 4.

Figure 4

Effect of partial blockade of NKCC1 co-transporter on action potential delays at GABAergic synapses. (A) Extracellular recordings of MUA evoked by electrical stimulation (E.S.) in the presence of the glutamate and GABA(B) receptor antagonists from the CA3 layer of P5 rat hippocampus (top: control, middle: 0.3 μM bumetanide and bottom: 20 μM bicuculline). On the right are shown corresponding cross-correlograms of the AP times versus stimulus. (B) Summary plot of the effects of low-bumetanide on synaptic GABA-evoked MUA. (C) Average cross-correlograms in control conditions (black) and in the presence of 0.3–0.6 μM bumetanide (red) (n = 4 slices; P2–5 rats). Dashed lines show SEM. Note that partial blockade of NKCC1 co-transporter increases AP delays and their jitter, and decreases APs number.