Table 5.
Frequency distribution of the FSH receptor haplotypes (SNP at nucleotide amino acid position 307 and 680)
| Haplotype | Controls n = 100 (%) | Primary amenorrhea subjects n = 48 (%) | Secondary amenorrhea subjects n = 38 (%) | ||
|---|---|---|---|---|---|
| n (%) | Odds Ratio (95% CI) | n (%) | Odds Ratio (95% CI) | ||
| Thr Thr(919)–Asn Asn (2039) | 13 (13) | 2 (4.16) | 0.29 | 3 (7.89) | 0.56 |
| Thr Thr(919)–Asn Ser (2039) | 12 (12)a,b | 8 (16.66)a | 1.47c | 9 (23.70)b | 2.07c |
| Thr Thr(919)–Ser Ser (2039) | 0 (0)a | 2 (4.16)a | 8.30c | 0 (0) | 0.26 |
| Thr Ala(919)–Asn Asn (2039) | 13 (13) | 2 (4.16) | 0.29 | 3 (7.89) | 0.57 |
| Thr Ala(919)–Asn Ser (2039) | 34 (34) | 15 (31.28) | 0.88 | 12 (31.59) | 0.89 |
| Thr Ala (919)–Ser Ser (2039) | 6 (6)a,b | 7 (14.58)a | 2.67c | 3 (7.89)b | 1.35c |
| Ala Ala(919)–Asn Asn (2039) | 5 (5)a | 6 (12.50)a | 2.71c | 5 (13.15) | 0.29 |
| Ala Ala(919)–Asn Ser (2039) | 10 (10)a | 6 (12.50)a | 1.28c | 02 (5.26) | 0.50 |
| Ala Ala(919)–Ser Ser (2039) | 7 (7) | 0 (0) | 0.13 | 1 (2.63) | 0.28 |
Values are numbers (percentage)
aThe frequency distribution of these haplotypes is significantly different between the controls and primary amenorrhea subjects (p < 0.05; Fischer’s test)
bThe frequency distribution of these haplotypes is significantly different between the controls and secondary amenorrhea subjects (p < 0.05; Fischer’s test)
cOdds ratio>1.0 is statistically significant