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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Nat Genet. 2010 Apr 25;42(5):441–447. doi: 10.1038/ng.571

Figure 3.

Figure 3

Forest and regional plots of significant associations for smoking behavior. (a–d) Shown are plots for smoking initiation (a,b) and smoking cessation (c,d) from meta-analyses of the TAG, Ox-GSK and ENGAGE consortia. Regional association plots show SNPs plotted by position on the chromosome against −log10 P value with each smoking phenotype. Estimated recombination rates (from HapMap-CEU) are plotted in light blue to reflect the local LD structure on a secondary y axis. The SNPs surrounding the most significant SNP (red diamond) are color coded to reflect their LD with this SNP (using pairwise r2 values from HapMap CEU): blue, r2 ≥ 0.8–1.0; green, 0.5–0.8; orange, 0.2–0.5; gray, <0.2. The gray bars at the bottom of the plot represent the relative size and location of genes in the region.