Figure 5.
Serum bactericidal titers against epidemic group A, W-135 and X strains. Eight strains were from Africa and 2 (LNP17592 and LNP19995) were Hajj-related sequence type (ST)–11, W-135 case isolates from France. All of the strains had heterologous PorA from the vaccine strains. The multilocus STs are shown in parentheses. The vaccine groups were as follows: Native outer membrane vesicle (OMV), Mutant (with “Mutant” denoting LpxL1 knockout strains of H44/76 and NZ98/254 expressing fHbp variant 1 and variant 2); Detergent OMV, WT (detergent-treated OMV from respective wild-type strain); and Al(OH)3 (aluminum hydroxide only).