Table 3.

ADC values in brain structures of good and poor outcome patients in 48-hour time-intervals following the cardiac arrest and in normal controls

Controls (N=14)		Good outcome (N=18)		Poor outcome (N=15)

Structure ADC ×10⁻⁶ mm²/sec median (IQR)	Time-interval from the cardiac arrest to MRI in hours	Structure ADC ×10⁻⁶ mm²/sec median (IQR)	p-value compared to controls	Structure ADC ×10⁻⁶ mm²/sec median (IQR)	p-value compared to controls	p-value between outcome groups
Temporal lobe: 788 (753-810)	0-192	827 (777-860)	0.047	683 (545-733)	0.002^*	<0.001^*
	0-48	843 (787-863)	0.432	788 (754-812)	0.953	0.400
	37-84	843 (815-864)	0.025	663 (513-687)	<0.001^*	0.001^*
	73-120	856 (820-862)	0.024	604 (533-664)	0.006^*	0.003^*
	109-156	813 (792-845)	0.224	733 (710-771)	0.300	0.183
	145-192	795 (766-820)	0.574	657 (628-686)	0.017^*	0.133
Occipital lobe: 754 (735-761)	0-192	784 (760-821)	0.004^*	619 (465-681)	<0.001^*	<0.001^*
	0-48	776 (762-797)	0.244	681 (680-725)	0.300	0.200
	37-84	819 (777-824)	0.007^*	563 (434-614)	0.002^*	0.001^*
	73-120	779 (752-827)	0.070	514 (462-624)	<0.001^*	0.001^*
	109-156	776 (754-813)	0.110	671 (648-678)	0.003^*	0.017^*
	145-192	787 (767-823)	0.018^*	620 (569-671)	0.017^*	0.133
Frontal lobe: 702 (676-735)	0-192	728 (686-745)	0.323	635 (508-702)	0.016^*	0.002^*
	0-48	694 (688-716)	0.953	682 (626-689)	0.244	0.700
	37-84	735 (697-736)	0.443	620 (450-702)	0.039	0.042
	73-120	706 (662-745)	0.868	535 (443-651)	0.006^*	0.029
	109-156	734 (684-778)	0.400	717 (627-734)	1.000	0.517
	145-192	728 (714-763)	0.192	523 (508-537)	0.017^*	0.133
Parietal lobe: 750 (711-764)	0-192	764 (727-799)	0.377	607 (517-698)	0.001^*	<0.001^*
	0-48	742 (720-757)	0.859	743 (709-753)	0.509	1.000
	37-84	773 (735-787)	0.400	549 (485-663)	0.001^*	0.008^*
	73-120	769 (661-804)	0.815	555 (509-654)	0.012^*	0.008^*
	109-156	793 (703-801)	0.535	648 (582-718)	0.300	0.117
	145-192	774 (739-806)	0.277	539 (517-562)	0.017^*	0.133
Hippocampus: 823 (792-849)	0-192	906 (868-924)	<0.001^*	839 (780-902)	0.694	0.015^*
	0-48	896 (881-910)	0.047^*	838 (813-882)	0.676	0.700
	37-84	920 (874-924)	0.038^*	840 (823-904)	0.439	0.408
	73-120	887 (867-917)	0.035^*	805 (701-873)	0.494	0.059
	109-156	916 (872-947)	0.002^*	780 (740-841)	0.300	0.117
	145-192	970 (912-975)	0.005^*	822 (780-864)	0.817	0.267
Thalamus: 771 (742-790)	0-192	794 (746-812)	0.416	753 (665-788)	0.235	0.087
	0-48	808 (782-808)	0.362	763 (738-769)	0.362	0.400
	37-84	802 (761-808)	0.443	720 (665-805)	0.224	0.210
	73-120	778 (717-836)	0.973	704 (623-788)	0.207	0.108
	109-156	773 (736-805)	0.913	788 (781-826)	0.244	0.383
	145-192	806 (772-818)	0.158	773 (773-773)	1.000	0.533
Caudate: 759 (740-783)	0-192	770 (738-810)	0.457	754 (717-812)	0.694	0.393
	0-48	755 (735-776)	0.953	731 (724-741)	0.121	0.700
	37-84	797 (755-810)	0.197	756 (568-812)	0.829	0.536
	73-120	783 (751-858)	0.238	785 (648-841)	0.718	0.662
	109-156	747 (728-770)	0.689	784 (761-813)	0.509	0.517
	145-192	763 (738-822)	0.798	816 (784-848)	0.100	0.533
Putamen: 719 (699-744)	0-192	746 (712-796)	0.056	684 (571-730)	0.037	0.001^*
	0-48	744 (738-755)	0.091	682 (661-712)	0.244	0.200
	37-84	748 (746-776)	0.038	615 (571-687)	0.001^*	0.002^*
	73-120	759 (741-819)	0.002^*	666 (502-699)	0.051	0.013^*
	109-156	735 (712-787)	0.224	800 (751-800)	0.197	0.833
	145-192	698 (692-782)	0.574	774 (746-801)	0.100	0.533
Corona Radiata: 701 (680-720)	0-192	732 (717-780)	0.001^*	692 (664-760)	0.985	0.026^*
	0-48	688 (687-697)	0.677	681 (672-688)	0.300	0.400
	37-84	736 (721-782)	0.020^*	751 (670-765)	0.403	0.470
	73-120	759 (726-793)	<0.001^*	720 (673-760)	0.602	0.142
	109-156	725 (720-729)	0.025^*	760 (666-773)	0.432	0.833
	145-192	726 (721-760)	0.035^*	601 (571-630)	0.017	0.133
Internal Capsule: 724 (685-746)	0-192	727 (701-762)	0.377	703 (650-749)	0.561	0.158
	0-48	718 (700-745)	0.953	724 (716-726)	0.768	1.000
	37-84	772 (717-774)	0.149	699 (685-749)	0.781	0.114
	73-120	739 (665-767)	0.664	663 (624-761)	0.353	0.282
	109-156	726 (670-739)	0.971	761 (705-806)	0.509	0.383
	145-192	727 (706-757)	0.442	659 (650-669)	0.033	0.133
Cerebellum: 683 (662-702)	0-192	699 (673-746)	0.129	667 (604-691)	0.180	0.007^*
	0-48	682 (623-758)	0.953	706 (687-711)	0.244	1.000
	37-84	732 (692-823)	0.110	611 (554-681)	0.072	0.042
	73-120	724 (699-782)	0.002^*	637 (603-691)	0.239	0.008^*
	109-156	696 (678-723)	0.400	680 (659-702)	0.859	0.517
	145-192	673 (667-718)	0.959	648 (638-657)	0.033	0.133
Pons: 665 (630-728)	0-192	737 (661-772)	0.056	706 (658-802)	0.235	0.988
	0-48	777 (744-867)	0.091	690 (687-763)	0.197	0.400
	37-84	763 (696-801)	0.046	791 (658-802)	0.305	0.837
	73-120	755 (660-803)	0.127	691 (627-794)	0.904	0.573
	109-156	672 (659-737)	0.535	794 (754-818)	0.091	0.117
	145-192	704 (644-751)	0.645	646 (578-714)	0.500	0.533

significant after adjustment for multiple comparisons

Number of scans in the good and poor outcome groups: 0-48 hours – 3 vs. 3; 37-84 hours – 7 vs. 9; 73-120 hours – 8 vs. 6; 109-156 hours – 7 vs. 3; 145-192 hours – 4 vs. 2