Table 5.

Sample Size per Group to detect an increase in the Serious Adverse Event Rate over the Control Rate

Control Rate	Increase 0.005	0.010	0.015	0.020	0.025	0.030	0.035	0.040	0.045	0.050
0.020	27,618	7,652	3,730	2,282	1,578	1,176	924	752	630	538
0.030	39,486	10,602	5,036	3,012	2,042	1,498	1,158	930	770	652
0.040	51,102	13,490	6,312	3,726	2,498	1,812	1,388	1,106	908	762
0.050	62,468	16,316	7,560	4,426	2,942	2,118	1,612	1,276	1,042	870