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. 2010 Aug 3;8(8):e1000442. doi: 10.1371/journal.pbio.1000442

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Migeotte et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Individual confocal sections of whole-mount embryos stained for F-actin (red). AVE cells were marked with the Hex-GFP transgene (green, staining with anti-GFP antibody in A and native GFP in B). After AVE migration is complete, at e6.5 (A) and e7.5 (B), AVE cells formed a single-layer epithelium and were squamous in wild-type embryos, with the exception of the most proximal cells, which were cuboidal. At e7.5, definitive endoderm cells expressing Hex-GFP (marked by an *) were present at the distal end of the primitive streak. In VE-deleted embryos, AVE cells had failed to reach the embryonic/extra-embryonic boundary. The Hex-GFP-expressing cells retained the columnar shape characteristic of migrating AVE cells and displayed a strong apical actin at e6.5 (arrow in A). Scale bars = 50 µm. Insets are 2×.