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. 2010 Aug 3;5(8):e11939. doi: 10.1371/journal.pone.0011939

Figure 3. Evaluation of S100A7 overexpression (nuclear/cytoplasmic) as a prognostic marker in HNSCC.

Figure 3

Kaplan–Meier estimation of cumulative proportion of disease-free survival: (a) Median time for disease-free survival (DFS; no recurrence/metastasis) in HNSCC patients showing nuclear immunostaining of S100A7 was 13 months, whereas in patients showing no/faint S100A7 immunostaining in nucleus median DFS was 70 months (p = 0.016); (b) In patients showing increased cytoplasmic S100A7 expression the median DFS was 14 months compared with HNSCC that showed mild or moderate cytoplasmic immunostaining (median DFS  = 70 months, p = 0.055). Time-dependent Positive and Negative Predictive Values (PPV(t), NPV(t)) of nuclear S100A7 expression. (c) PPV(t) for time to cancer relapse for 49 HNSCC patients with S100A7+ (solid line) and for all 77 HNSCC patients with survival data (dashed line); d) NPV(t) for time to cancer relapse for 28 HNSCC patients with S100A7− (solid line).