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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Gene Ther. 2010 Apr 29;17(8):939–948. doi: 10.1038/gt.2010.47

Figure 3.

Figure 3

Efficient and stable MGMTP140K-mediated in vivo selection in the dog model. A gammaretroviral vector expressing the P140K mutant MGMT mediates efficient selection after treatment with temozolomide and O6BG. Treatments were well tolerated, and resulted in chemoprotection. This research was originally published in Blood. Brian C. Beard, Reeteka Sud, Kirsten A. Keyser, Christina Ironside, Tobias Neff, Sabine Gerull, Grant D. Trobridge and Hans-Peter Kiem. Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients. Blood. 2009; Vol. 113, pp. 5094-5103. © the American Society of Hematology.