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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Gene Ther. 2010 Apr 29;17(8):939–948. doi: 10.1038/gt.2010.47

Figure 4.

Figure 4

Retroviral integration site profiles in dog and nonhuman primate long term repopulating sites. The top panel shows the location of integration sites relative to the transcription start sites of Refseq genes for 114 gamma-, 327 lenti- and 341 foamy retroviral intergrants in dog long-term repopulating cells. The bottom panel shows MLV-based gammaretroviral integration sites and lentiviral integration sites (HIV and SIV) in nonhuman primate repopulating cells. Asterisks mark significant differences from a random data set, * is p<0.01 and ** is p<0.001. Frequencies are normalized as the percentage of total integrants per kilobase. This research was originally published in Human Gene Therapy. Brian C. Beard, Kirsten A. Keyser, Grant D. Trobridge, Laura J. Peterson, Daniel G. Miller, Michael Jacobs, Rajinder Kaul, Hans-Peter Kiem. Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, or foamy virus. Human Gene Therapy. 2007; Vol. 18, pp. 423-434, and in Molecular Therapy. Brian C. Beard, David Dickerson, Kate Beebe, Christina Gooch, James Fletcher, Tulin Okbinoglu, Daniel G Miller, Michael A Jacobs, Rajinder Kaul, Hans-Peter Kiem, and Grant D. Trobridge. 2007; Vol. 15 pp. 1356–1365.