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Comparison of the suitability of animal models for HSC gene therapy
| Property | Mouse | NOD/SCID xenotransplant | Dog | Nonhuman Primate |
|---|---|---|---|---|
| Similarity of host cell receptors | + | +++ | + | ++ |
| Cycling of HSCs | + | +++ | +++ | +++ |
| Telomerase activity | + | +++ | +++ | +++ |
| Multilineage long term repopulation | + | + | +++ | +++ |
| Clinical translation of transplantation protocols | + | + | +++ | +++ |
| Relevance of genotoxicity assays | + | ++ | ++ | +++ |
| Overall ability to predict HSC gene transfer efficiency in humans | + | ++ | +++ | +++ |
| Cost | +++ | ++ | + | + |
