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. Author manuscript; available in PMC: 2011 Aug 10.
Published in final edited form as: Biochemistry. 2010 Aug 10;49(31):6715–6726. doi: 10.1021/bi1008744

Scheme 2. LpxH and LpxI catalyze UDP-diacylglucosamine hydrolysis by different mechanisms.

Scheme 2

Oxygen from the water attacking the α-phosphate in the LpxH-catalyzed reaction is shown in red, whereas oxygen from the water attacking the β-phosphate in the LpxI-catalyzed reaction is shown in magenta.