FIGURE 4. Radioiodine Imaging of Xenograft Tumors.

A) LnCaP and Panc-1 xenografted tumors were infected with Ad5PB_RSV-NIS at 10¹¹ vp. At time points post-infection an injection of 0.5 mCi ⁹⁹Tc was given IP to all mice. Images were captured using a noninvasive micro SPECT-CT imaging system one hour after radioisotope administration. B) Kinetics of imaging were established by quantifying ⁹⁹Tc tumor uptake using the PMOD Biomedical Image Quantification and Kinetic Modeling Software (PMOD Technologies, Switzerland). The level of ⁹⁹Tc uptake by the tumor was expressed as tumor activity in μCi.