Table 4.
1:1 propensity score matched analysis of outcomes presented in Table 3. Matching was performed with the greedy matching algorithm
| Outcome | Within-center analyses |
Pooled† | |||
|---|---|---|---|---|---|
| British Columbia* | Pennsylvania | New Jersey | Horizon | ||
| Myocardial infarction hospitalization | |||||
| Cumulative risk analysis (odds ratios) | |||||
| Matched by universal PS | 1.26 [0.97, 1.62] | 1.06 [0.68, 1.64] | 1.30 [0.81, 2.08] | 0.97 [0.52, 1.78] | 1.19 [0.98, 1.44] |
| Per cent of exposed patients matched | 98.4% | 91.7% | 94.3% | 95.0% | 95.4% |
| Matched by hd-PS | 1.19 [0.92, 1.54] | 1.31 [0.81, 2.11] | 1.34 [0.81, 2.20] | 1.05 [0.50, 2.17] | 1.21 [1.00, 1.48] |
| Per cent of exposed patients matched | 95.6% | 74.6% | 79.1% | 84.8% | 85.2% |
| Time-to event analysis (hazard ratios) | |||||
| Matched by universal PS | 1.24 [0.91, 1.69] | 1.59 [0.78, 3.25] | 1.64 [0.80, 3.36] | 0.81 [0.37, 1.76] | 1.26 [0.98, 1.62] |
| Per cent of exposed patients matched | 98.4% | 91.7% | 94.3% | 95.0% | 95.4% |
| Matched by hd-PS | 1.22 [0.89, 1.68] | 3.30 [1.25, 8.70] | 0.91 [0.45, 1.83] | 0.52 [0.21, 1.27] | 1.17 [0.90, 1.52] |
| Per cent of exposed patients matched | 95.8% | 73.5% | 77.5% | 86.4% | 85.0% |
| Hospitalization for revascularization | |||||
| Cumulative risk analysis (odds ratios) | |||||
| Matched by universal PS | 1.52 [1.11, 2.06] | 1.00 [0.75, 1.34] | 0.97 [0.75, 1.27] | 1.26 [0.94, 1.68] | 1.15 [1.00, 1.33] |
| Per cent of exposed patients matched | 98.4% | 91.7% | 94.3% | 95.0% | 95.4% |
| Matched by hd-PS | 1.06 [0.81, 1.40] | 1.00 [0.72, 1.37] | 0.91 [0.67, 1.22] | 1.46 [1.07, 2.00] | 1.08 [0.93, 1.26] |
| Per cent of exposed patients matched | 96.3% | 74.4% | 78.2% | 84.9% | 85.3% |
| Time-to event analysis (hazard ratios) | |||||
| Matched by universal PS | 1.47 [1.00, 2.15] | 0.85 [0.56, 1.29] | 0.80 [0.55, 1.16] | 1.26 [0.89, 1.77] | 1.07 [0.89, 1.29] |
| Per cent of exposed patients matched | 98.4% | 91.7% | 94.3% | 95.0% | 95.4% |
| Matched by hd-PS | 1.48 [1.00, 2.19] | 0.88 [0.57, 1.38] | 0.73 [0.49, 1.10] | 1.58 [1.09, 2.30] | 1.14 [0.94, 1.39] |
| Per cent of exposed patients matched | 96.1% | 76.0% | 78.2% | 84.9% | 85.6% |
PS Propensity score; hd-PS High-dimensional propensity score.
*
Within-center odds ratios are estimated by logistic regression.
†
Pooled odds ratios are estimated by conditional logisitic regression stratified by center.