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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Trends Cogn Sci. 2010 Jun 16;14(8):365–375. doi: 10.1016/j.tics.2010.05.003

Figure 1.

Figure 1

A working model of DNC mechanisms. DNC signaling proteins are often found in long, thin spines with narrow spine necks in the superficial layers of monkey dorsolateral PFC. A. Immunoelectron micrograph of HCN channels (red arrows) on a spine neck across from an asymmetric (presumed glutamatergic) synapse, and on the parent dendrite. HCN channels in spines appear to gate synaptic inputs onto the spines, while those on dendrites may regulate excitability (adapted from [7]). B. Immunoelectron micrograph of HCN channels (red arrows) on a spine head next to the post-synaptic density of an asymmetric (presumed glutamatergic) synapse (adapted from [7]). C. Working model of molecular mechanisms that weaken PFC network connectivity. D. Working model of molecular mechanisms that strengthen network connectivity. For both C and D, molecules that strengthen connectivity are shown in green; those that weaken connectivity are shown in red.