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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Trends Cogn Sci. 2010 Jun 16;14(8):365–375. doi: 10.1016/j.tics.2010.05.003

Figure 5.

Figure 5

ACh strengthens PFC network connectivity. A. A working model showing that ACh may strengthen PFC network connections through direct stimulation of α7 nicotinic receptors on spines [54], and indirectly through stimulation of muscarinic receptors which in turn closes KCNQ2/3 channels. Nicotinic α7 receptors are shown in navy blue due to their genetic alteration in some families with schizophrenia; ACh is shown in purple due to its decline with normal aging. B. Systemic administration of the α7 receptor agonist, GTS-21, to monkeys partially rescues the deficits in working memory induced by the NMDA receptor blocker, ketamine. Figure adapted from [52] with the kind permission of A.V. Terry, Jr..