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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Curr Opin Pharmacol. 2010 Jun 4;10(4):408–424. doi: 10.1016/j.coph.2010.04.015

Figure 3. Acylated GRL increases thymic size and cellularity in aging mice.

Figure 3

(A) Acylated GRL is infused for 2 weeks via s/c osmotic pumps after which thymic size, weight and cellularity is examined. A significant increase in thymic size in 20m mice infused with acylated GRL compared to vehicle controls. (B) GRL infusion is also associated with increased cellularity and much clearer delineation of cortex from medulla as well as a well defined CMJ, the site where progenitors enter the thymus. (C) Moreover, acylated GRL infusion into aged (20m) mice increases the total thymocyte numbers and thymic weight (not shown) compared to vehicle (Sham) control animals. More detailed studies on the prothymic effects of GRL can be found in Ref. 97.