3D vasculature representations were coregistered with the tumor, rending the ability to identify the altered pre-existing vessels (black arrows) and newly generated vessels (arrowheads). As shown here, they are taken at 30° from the sagittal plane of the brain, for an early and late time point and for representative glioma models presenting different angiogenic behaviors: primary astrocyte-implanted animal (panel A, day 7, left, and day 29, right), C6 (panel B, day 5, left, and day 21, right), U87 (panel C, day 7, left, and day 27, right) and GL261 gliomas (panel D, day 8, left, and day 23, right).