Table 5.
Adjusteda Odds Ratios for Progression of Coronary Artery Calcification From Follow-up Year 15 to Year 20, According to 3 Indices of Year 15 Body Mass Indexb and Its History, Coronary Artery Risk Development in Young Adults (CARDIA) Study, 1985–2006
| BMI at Year 0 |
Ptrend | |||||
| Q1 (19.8)c | Q2 (21.6) | Q3 (23.4) | Q4 (25.3) | Q5 (29.7) | ||
| No. of cases/no. of participants | 24/448 | 25/449 | 40/449 | 56/449 | 62/448 | |
| Unadjusted % | 5.4 | 5.6 | 8.9 | 12.5 | 13.8 | |
| Model 1 OR (95% CI) | Referent | 0.9 (0.5, 1.6) | 1.1 (0.6, 1.9) | 1.4 (0.8, 2.4) | 2.0 (1.1, 3.4) | <0.01 |
| Model 2 OR (95% CI) | Referent | 0.8 (0.4, 1.5) | 0.9 (0.5, 1.7) | 1.2 (0.7, 2.0) | 1.5 (0.8-2.6) | 0.08 |
| Linear Slope of BMI From Year 0 to Year 15 |
||||||
| Q1 (−0.01) | Q2 (0.12) | Q3 (0.22) | Q4 (0.36) | Q5 (0.61) | ||
| No. of cases/no. of participants | 51/448 | 50/449 | 43/449 | 41/449 | 22/448 | |
| Unadjusted % | 11.4 | 11.1 | 9.6 | 9.1 | 4.9 | |
| Model 1 OR (95% CI) | Referent | 1.0 (0.6, 1.5) | 0.7 (0.4, 1.1) | 0.7 (0.4, 1.1) | 0.4 (0.3, 0.8) | <0.01 |
| Model 2 OR (95% CI) | Referent | 0.9 (0.6, 1.4) | 0.6 (0.4, 1.0) | 0.6 (0.3, 0.9) | 0.4 (0.2, 0.6) | <0.01 |
| Fluctuation in BMI During 15 Years |
||||||
| Q1 (0.40) | Q2 (0.69) | Q3 (0.96) | Q4 (1.35) | Q5 (2.17) | ||
| No. of cases/no. of participants | 31/448 | 35/449 | 42/449 | 51/449 | 48/448 | |
| Unadjusted % | 6.9 | 7.8 | 9.4 | 11.4 | 10.7 | |
| Model 1 OR (95% CI) | Referent | 1.1 (0.7, 1.9) | 1.5 (0.9, 2.5) | 2.1 (1.2, 3.5) | 2.2 (1.3, 3.9) | <0.01 |
| Model 2 OR (95% CI) | Referent | 1.0 (0.6, 1.8) | 1.4 (0.8, 2.3) | 1.9 (1.1, 3.3) | 2.0 (1.1, 3.6) | <0.01 |
Abbreviations: BMI, body mass index; CI, confidence interval; OR, odds ratio; Q, quintile.
This table presents results from 2 separate models with different covariates. Each model included BMI at year 0, slope of BMI from year 0 to year 15, fluctuation in BMI from year 0 to year 15, and covariates measured at year 15. Covariates for model 1 were age, sex, race/ethnicity, study center, cigarette smoking, and physical activity. Covariates for model 2 were those for model 1 plus systolic blood pressure, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, and fasting glucose.
Weight (kg)/height (m)2.
Numbers in parentheses, median value.