Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Th17 pathway. TIP-dendritic cells (TIP-DCs), secondary to a stimulus, produce IL-23 and TNF-α, which sustain differentiation of Th precursors into Th17 cells (originally initiated by IL-6 and TGF-β). As a result, activated Th17 cells secrete IL-17 and IL-22, resulting in keratinocyte hyperproliferation and plaque formation.19
