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Responses of peak activity of cardiac sympathetic afferents to repeated LA injection of ET-1 (2 μg) with vehicle (PBS, 1.5 ml, i.v., n= 7, A) or treatment with BQ-123 (0.1 mg kg−1, i.v., n= 9, B). C, neurohistograms of summated 2 s discharge activity from all nine cardiac afferents in response to ET-1 stimulation before (a) and after (b) treatment with BQ-123. Columns and error bars represent means ±s.e.m.*P < 0.05 compared with control. †P < 0.05 post-BQ-123 vs. pre-BQ-123.
