Table 15.1.1.

Encephalitogenic Peptides of MBP, PLP, and MOG in Various Inbred Mouse Strains

Mouse strain	H-2 type	Peptide	Sequencea	Reference
PL/J, B10.PL	H-2u	MBPAc1-11	Ac-ASQKRPQRHG	Zamvil et al. (1986)
		PLP178-191	NTWTTCQSIAFPSK	Unpublished (B10.PL)
		MBP35-47	TGILDSIGRFFSG	Zamvil et al. (1988)
		PLP43-64	EKLIETYFSKNYQDYEYLINVI	Whitham et al. (1991)
SJL	H-2s	MBP89-101	VHFFKNIVTPRTP	Sakai et al. (1988)
		MBP84-104	VHFFKNIVTPRTPPPSQGKGR	Tan et al. (1992)
		PLP139-151b	HSLGKWLGHPDKF	Tuohy et al. (1993)
		PLP104-117	KTTICGKGLSATVT	Tuohy and Thomas (1993)
		PLP178-191	NTWTTCQSIAFPSK	Greer et al. (1992)
		PLP57-70	YEYLINVIHAFQYV	Greer et al. (1996)
		MOG92-106	DEGGYTCFFRDHSYQ	Amor et al. (1994)
(PL/J X SJL) F1	H-2s/u	MBPAc1-11	Ac-ASQKRPQRHG	Zamvil et al. (1986)
		PLP43-64	EKLIETYFSKNYQDYEYLINVI	Whitham et al. (1991)
		PLP139-151	HSLGKWLGHPDKF	Whitham et al. (1991)
C57BL/6	H-2b	MOG35-55	MEVGWYRSPFSRVVHLYRNGK	Mendel et al. (1995)
		PLP178-191	NTWTTCQSIAFPSK	Tompkins et al. (2002)
C3H	H-2k	PLP103-116	YKTTICGKGLSATV	Tuohy et al. (1988a)
SWR	H-2q	PLP215-232	PGKVCGSNLLSICKTAEF	Endoh et al. (1990)
(SJL X B10.PL) F1	H-2s/q	PLP139-151	HSLGKWLGHPDKF	Unpublished
		PLP178-191	NTWTTCQSIAFPSK	Unpublished
		MBPAc1-11	Ac-ASQKRPQRHG	Unpublished
(SJLX C3H/HeJ)F1c	H-2s/k	PLP190-209	SKTSASIGSLCADARMYGVL	Muller et al. (2000)
		PLP215-232	PGKVCGSNLLSICKTAEFQ	Greer et al. (1996)
BALB/cPtc	H-2d	PLP178-191	NTWTTCQSIAFPSK	Greer et al. (1992)
NOD	H-2g7	PLP56-70	DYEYLINVIHAFQYV	Girvin et al. (2000)
		MOG35-55	MEVGWYRSPFSRVVHLYRNGK	Slavin et al. (1998)

^aSequences for MBP peptides are based on different species variants of MBP, which have different numbering systems; sequences for PLP and MOG peptides are based on the mouse sequence. The reader is urged to consult the indicated references for more detailed information.

The PLP_139-151 sequence has a serine (S) for cysteine (C) substitution at position 140 to enhance solubility.

The EAE observed in these mice is nonclassical. In (SJL X C3H/HeJ)F1 mice, the disease causes imbalance and axial rotary movement (rotary EAE). In BALB/cPt, mice show lack of balance and forelimb paralysis in the absence of hindlimb paralysis.