Figure 4.

Histopathology of WT and HD striatum and cerebral cortex. Hematoxylin-and-eosin and Oil red O staining of the cortex and striatum of WT and HD mice with or without GPA treatment. Note vacuolation (arrows) in the HD striatum which is more severe following GPA treatment. The GPA-treated HD sriatum showed more severe vacuolation than the GPA-treated HD cortex. Oil red O staining did not reveal any significant lipid accumulation in any of the sections. Insets are higher magnification of the respective boxed areas showing the vacuolation. Scale bar = 100 µm.