Table 1.
Significance (P ≤ .01) of OD values (U Mann and Whitney t-test) and percentage of AD positive patients on well plates coated with tryptophan-derivative conjugates. OD values for each tryptophan-derivative conjugate were subtracted from those on BSA well plates. Percentages were calculated as follows: number of patients with OD values above mean OD value of controls +2 standard deviations.
| Conjugates coated on well plates | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Isotype | Kyn | 3-0HKyn | Kyna | Quina | Quinald | 3-OHAnthra | Anthra | Xantha | |
| G | Significance | 0.0836 | 0.5746 | 0.5758 | 0.8793 | 0.7513 | 0.0194 | 0.1576 | 0.0635 |
| Percentage | 25.4% | 10.9% | 10.9% | 7.2% | 16.3% | 9.0% | 14.7% | 20.0% | |
| M | Significance | 0.8275 | 0.8741 | 0.9784 | 0.0000 | 0.3450 | 0.2294 | 0.8172 | 0.9895 |
| Percentage | 29% | 9.0% | 18.1% | 7.2% | 32.7% | 14.5% | 21.8% | 21.8% | |
| A | Significance | 0.0015 | 0.0001 | 0.0000 | 0.0027 | 0.0119 | 0.0034 | 0.0026 | 0.0005 |
| Percentage | 38.1% | 58.1% | 61.8% | 65.4% | 43.6% | 50.9% | 54.5% | 63.6% | |
|
| |||||||||
| Isotype | Pico | W | 5-HW | 5-HT | Mel | 5-HIAA | 5-HTol | 5-MTol | |
|
| |||||||||
| G | Significance | 0.0790 | 0.9042 | 0.0000 | 0.0118 | 0.3873 | 0.0878 | 0.4244 | 0.6936 |
| Percentage | 12.7% | 24.1% | 27.5% | 20.6% | 20.6% | 10.3% | 10.3% | 6.8% | |
| M | Significance | 0.9737 | 0.0007 | 0.0000 | 0.7928 | 0.4906 | 0.4181 | 0.3696 | 0.6941 |
| Percentage | 23.6% | 3.4% | 3.4% | 10.3% | 10.3% | 24.1% | 6.8% | 3.4% | |
| A | Significance | 0.0011 | 0.0878 | 0.2836 | 0.0001 | 0.0018 | 0.0001 | 0.0010 | 0.0015 |
| Percentage | 65.4% | 10.3% | 13.7% | 62% | 51.7% | 58.6% | 41.3% | 51.7% | |