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A model for the ATPase-cycle-dependent regulation of bacterial MutL endonuclease activity. Free MutL exists as an ATP-bound form whose endonuclease activity is inactive, but preferably binds to a MutS-mismatch complex. The interaction with the MutS-mismatch complex induces the ATP hydrolysis of MutL, resulting in the stimulation of its endonuclease activity. Adapted from the work of Fukui et al. [34].
