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. 2010 Jun 1;285(32):24487–24493. doi: 10.1074/jbc.M110.136820

FIGURE 3.

FIGURE 3.

Timp4−/− mice experience significantly higher mortality following MI. A, rupture-related survival of Timp4+/+ and Timp4−/− mice following MI or sham operation; n = 27 for Timp4−/− MI and n = 20 for Timp4+/+ MI; *, p < 0.05 versus sham; ‡, p < 0.05 versus Timp4+/+ MI. B, representative macroscopic cross-sectional images of Timp4+/+ and Timp4−/− hearts at indicated times after sham operation or MI. C, functional and structural analyses showing fractional shortening, LV end-diastolic dimension (LVEDD), LV end-diastolic pressure (LVEDP), and LV peak rates of pressure-rise and pressure-fall (±dP/dt) in mice at 1-week post-sham or post-MI. Data represent mean ± S.E.; n = 6/group; *, p < 0.05 versus corresponding sham group.