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Immunostaining for pleiotrophin in lymph nodes (a) and RT-PCR of SOCS3 in large intestinal tissues (b). Pleiotrophin expression was diminished by the treatment with HA900 (a). Ratio of the intensity (SOCS3/glyceraldehyde-3-phosphate dehydrogenase (GAPDH)) showed that HA900 treatment up-regulated mRNA expression of SOCS3 (b).
