TABLE 3.

Sensitivity profile of wild-type, MVN-resistant and 2G12-resistant HIV-1 NL4.3 virus

Agenta	WT	MVN-res	Resistance/sensitivityb	2G12-res	Resistance/sensitivityb
			-fold		-fold
MVN	6 ± 1	576 ± 84	[96]	10 ± 4	[2]
CV-N	16 ± 10	60 ± 18	[4]	45 ± 35	[3]
HHA	4 ± 0.8	12 ± 4	[3]	0.5 ± 0.2	[8]*
GNA	15 ± 8	7 ± 1	[2]*	2 ± 1	[7]*
UDA	284 ± 79	718 ± 340	[3]	36 ± 9	[8]*
PRM-S	1,901 ± 11	9,363 ± 1,165	[5]	4,615 ± 2,714	[2]
2G12 mAbc	1,310 ± 530	>50,000	[>38]	>50,000	[>38]
b12 mAbc	380 ± 110	2,740 ± 50	[7]	640 ± 220	[2]
PRO 2000	342 ± 2	298 ± 216	[1]	196 ± 96	[2]*
AMD3100	19 ± 5	8 ± 3	[2]*	5 ± 0.1	[4]*

^a IC₅₀ (drug concentration in nm required to inhibit virus replication in MT-4 cells by 50%).

^b Values in brackets represent the degree (-fold) of resistance or sensitivity (indicated by an asterisk) of the test agents, compared with wild type virus. Values are mean ± S.E. from 2–7 separate experiments.

^c IC₅₀ (drug concentration in ng/ml required to inhibit virus replication in MT-4 cells by 50%).