FIGURE 4.
Structure of isopropyl alcohol-bound S. aureus fRMsr and its comparison with the substrate-bound form. A, the active site of fRMsrisopro. Interactions between isopropyl alcohol (Iso-propanol) and active site residues are represented by dotted lines. B, comparison of active sites between fRMsrisopro (light blue) and fRMsrsub (light gray). The active site residues of fRMsrisopro and fRMsrsub are superimposed. Disulfide bonds between Cys68 and Cys102 and isopropyl alcohol in fRMsrisopro are shown by yellow and light pink sticks, respectively, and substrate Met-R-O (Met-R-O) in fRMsrsub is shown by a light green stick.