Table 2.

Activations by event-related linear contrasts in the MID task^*

	Talairach Coordinates:			|t-value|:	uncorrected p
Reward vs nonincentive anticipation
Controls
L Nucleus accumbens	−9	11	−4	4.906	<.0001
R Nucleus accumbens	10	11	−5	3.914	<.001
L Putamen	−17	3	−4	5.242	<.0001
L thalamus	−5	−22	5	6.659	<.00001
R thalamus	−3	−19	4	5.689	<.00001
L substantia nigra	−9	−11	−7	6.675	<.00001
L orbitofrontal cortex	−19	31	−16	4.890	<.0001
AED
L Nucleus accumbens	−8	11	1	5.690	<.00001
R Nucleus accumbens	14	10	−6	4.640	<.00001
L dorsolateral thalamus	−10	−10	17	4.904	<.0001
L thalamus	−8	−14	5	4.821	<.0001
Mesial frontal cortex	2	46	−8	6.291	<.00001
Posterior cingulate gyrus	3	−54	18	6.287	<.0001
L orbitofrontal cortex	−33	40	−3	5.544	<.0001
Loss-avoidance vs nonincentive anticipation
No significant activations in either subject group
Reward vs nonreward feedback
Controls
R Nucleus accumbens	9	8	−6	6.412	<.00001
L Nucleus accumbens	−9	11	−6	5.311	<.0001
L Putamen	−23	3	4	5.398	<.0001
R Putamen	25	7	9	5.171	<.0001
Mesial orbitofrontal cortex	−4	45	−9	5.622	<.0001
R orbitofrontal cortex	29	39	−9	5.400	<.0001
AED
R Nucleus accumbens	11	13	−1	7.218	<.000001
L Nucleus accumbens	−10	13	−1	9.126	<.0000001
L Putamen	−21	3	6	5.339	<.0001
R Putamen	20	−1	−6	5.109	<.0001
Mesial frontal cortex	3	46	−1	6.791	<.000001
Mesial frontal cortex	3	35	4	7.570	<.000001
Loss vs nonloss feedback
Controls
R Insula	36	13	−4	5.819	<.00001
AED
R Insula	39	12	−6	4.678	<.001

^*Activation maxima listed here are significant at q < .05 per False Discovery Rate