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. 2010 May 18;2010:467316. doi: 10.1155/2010/467316

Table 4.

Changes in anthropometric, glucose metabolism, and lipid variables at 8 and 12 weeks by treatment arm.

Arm 1 + 4 (placebo) Arm 2 (3 tablets) Arm 3 (6 tablets) P-value P-value P-value
Value Change from baseline Value Change from baseline Value Change from baseline (1+4 versus 2) (1+4 versus 3) (2 versus 3)
Weight (kg)
 8 weeks 96.6 ± 2.8 3.5 ± 0.5 94.9 ± 2.4 3.1 ± 0.5 100.2 ± 3.1 3.3 ± 0.5 .50 .77 .71
 12 weeks 96.2 ± 2.8 3.9 ± 0.6 95.9 ± 2.4 3.2 ± 0.5 98.9 ± 3.1 3.8 ± 0.6 .39 .86 .50
Waist (cm)
 8 weeks 105.9 ± 2.2 3.4 ± 0.7 104.6 ± 2.0 2.6 ± 0.7 107.7 ± 2.3 2.4 ± 0.7 .84 .43 .33
 12 weeks 105.4 ± 2.2 3.9 ± 0.7 105.1 ± 2.1 3.4 ± 0.8 107.0 ± 2.2 2.8 ± 0.7 .56 .64 .29
BMI (kg/m2)
 8 weeks 33.7 ± 0.7 1.2 ± 0.2 33.7 ± 0.7 1.1 ± 0.2 34.6 ± 0.8 1.2 ± 0.2 .60 .77 .83
 12 weeks 33.6 ± 0.8 1.4 ± 0.2 34.1 ± 0.7 1.1 ± 0.2 34.2 ± 0.8 1.3 ± 0.2 .43 .83 .58
BP-systolic (mmHg)
 8 weeks 126.9 ± 2.5 3.4 ± 1.3* 124.7 ± 2.7 4.7 ± 1.5 127.1 ± 2.5 −2.0 ± 2.3 .59 .57 .29
 12 weeks 127.9 ± 2.4 −2.3 ± 1.4 127.9 ± 2.4 −0.6 ± 1.9 128.1 ± 2.3 −0.1 ± 3.1 .58 .47 .87
BP-diastolic (mmHg)
 8 weeks 79.1 ± 1.4 4.9 ± 1.3 80.3 ± 1.5 2.5 ± 1.0* 82.8 ± 1.5 −2.3 ± 1.2 .17 .13 .88
 12 weeks 80.6 ± 1.6 −3.4 ± 1.3* 81.3 ± 1.6 −2.0 ± 1.2 81.0 ± 2.0 −3.3 ± 1.9 .51 .98 .54
F. glucose (mmol/L)
 8 weeks 5.52 ± 0.09 0.16 ± 0.06 5.55 ± 0.13 0.07 ± 0.09 5.64 ± 0.07 0.29 ± 0.08 .40 .23 .05
 12 weeks 5.54 ± 0.09 0.18 ± 0.07* 5.52 ± 0.10 0.03 ± 0.08 5.62 ± 0.13 0.24 ± 0.09* .19 .59 .08
Glucose 2pp (mmol/L)
 8 weeks 6.49 ± 0.29 0.43 ± 0.29 6.97 ± 0.36 −0.13 ± 0.35 7.21 ± 0.41 0.47 ± 0.33 .22 .94 .21
 12 weeks 6.57 ± 0.33 0.51 ± 0.34 6.81 ± 0.27 −0.36 ± 0.32 6.81 ± 0.44 0.04 ± 0.34 .07 .32 .41
F. insulin (pmol/L)
 8 weeks 86.3 ± 10.5 −8.4 ± 6.7 93.8 ± 11.1 27.2 ± 9.4 79.6 ± 5.4 20.6 ± 8.1* .10 .28 .57
 12 weeks 87.0 ± 8.5 −7.7 ± 6.5 107.0 ± 14.2 −20.5 ± 9.8* 96.4 ± 16.6 −2.8 ± 11.3 .32 .71 .19
Insulin 2pp (pmol/L)
 8 weeks 460.8 ± 77.5 −114.7 ± 63.5 579.7 ± 89.1 −213.9 ± 118.9 550.4 ± 101.7 −57.5 ± 63.9 .40 .63 .21
 12 weeks 705.8 ± 85.0 130.3 ± 61.2* 863.0 ± 117.6 35.4 ± 72.6 655.9 ± 82.5 56.5 ± 61.0 .30 .42 .82
Cholesterol (mmol/L)
 8 weeks 5.35 ± 0.20 −0.13 ± 0.13 5.26 ± 0.19 −0.19 ± 0.13 5.20 ± 0.24 −0.26 ± 0.14 .73 .47 .72
 12 weeks 5.16 ± 0.17 0.32 ± 0.12* 5.17 ± 0.16 −0.18 ± 0.11 5.30 ± 0.23 −0.16 ± 0.13 .42 .35 .90
LDL (mmol/L)
 8 weeks 3.24 ± 0.16 −0.08 ± 0.12 3.15 ± 0.18 0.06 ± 0.12 3.23 ± 0.20 −0.10 ± 0.11 .40 .91 .35
 12 weeks 2.98 ± 0.14 −0.24 ± 0.12 3.08 ± 0.15 0.10 ± 0.11 3.24 ± 0.17 0.02 ± 0.11 .04 .10 .64
TG (mmol/L)
 8 weeks 2.60 ± 0.36 −0.02 ± 0.39 2.37 ± 0.21 0.55 ± 0.14 2.05 ± 0.19 0.50 ± 0.18* .17 .22 .89
 12 weeks 2.41 ± 0.23 −0.20 ± 0.19 2.28 ± 0.22 −0.59 ± 0.12 2.27 ± 0.32 −0.25 ± 0.24 .14 .87 .21
HDL (mmol/L)
 8 weeks 1.07 ± 0.04 0.01 ± 0.02 1.06 ± 0.03 −0.01 ± 0.02 1.05 ± 0.03 −0.04 ± 0.02 .56 .13 .36
 12 weeks 1.07 ± 0.04 0.00 ± 0.02 1.07 ± 0.03 −0.00 ± 0.02 1.06 ± 0.04 −0.03 ± 0.03 .83 .29 .40
Chol/HDL
 8 weeks 5.1 ± 0.2 −0.2 ± 0.1 5.0 ± 0.2 −0.1 ± 0.1 5.0 ± 0.2 −0.1 ± 0.1 .90 .59 .69
 12 weeks 4.9 ± 0.2 0.3 ± 0.1* 4.9 ± 0.2 −0.2 ± 0.1 5.1 ± 0.2 0.0 ± 0.1 .41 .06 .30
TG/HDL
 8 weeks 5.9 ± 1.0 0.1 ± 1.1 5.3 ± 0.6 1.1 ± 0.4 4.6 ± 0.4 −0.8 ± 0.4 .24 .37 .79
 12 weeks 5.3 ± 0.5 −0.5 ± 0.5 5.0 ± 0.5 1.3 ± 0.3 5.1 ± 0.8 −0.3 ± 0.6 .23 .76 .15
HOMA
 8 weeks 3.0 ± 0.4 −0.2 ± 0.3 3.3 ± 0.4 0.9 ± 0.4* 2.8 ± 0.2 −0.6 ± 0.3 .12 .37 .51
 12 weeks 3.1 ± 0.3 −0.1 ± 0.3 3.7 ± 0.5 −0.7 ± 0.4 3.7 ± 0.9 0.3 ± 0.6 .38 .49 .13

Data expressed as mean ± SE. *P < .05, P < .01 compared to baseline.